ABSTRACT
Hyperglycemia in the diabetic state increases oxidative stress and antioxidant therapy can be strongly correlated with decreased risks for diabetic complications. The purpose of this study is to determine antioxidant effect of garlic and aged black garlic in animal model of type 2 diabetes. The antioxidant activity of garlic and aged black garlic was measured as the activity in scavenging free radicals by the trolox equivalent antioxidant capacity (TEAC) assay. Three week-old db/db mice were fed AIN-93G diet or diet containing 5% freeze-dried garlic or aged black garlic for 7 weeks after 1 week of adaptation. Hepatic levels of lipid peroxides and activities of antioxidant enzymes were measured. TEAC values of garlic and aged black garlic were 13.3 +/- 0.5 and 59.2 +/- 0.8 micromol/g wet weight, respectively. Consumption of aged black garlic significantly decreased hepatic thiobarbituric acid reactive substances (TBARS) level compared with the garlic group which showed lower TBARS level than control group (p<0.05). Activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) of garlic and aged black garlic group were significantly elevated compared to the control group. Catalase (CAT) activity of aged black garlic group was increased compared with the control group. These results show that aged black garlic exerts stronger antioxidant activity than garlic in vitro and in vivo, suggesting garlic and aged black garlic, to a greater extent, could be useful in preventing diabetic complications.
Subject(s)
Aged , Animals , Humans , Mice , Antioxidants , Catalase , Chromans , Diabetes Complications , Diabetes Mellitus , Diabetes Mellitus, Type 2 , Diet , Free Radicals , Garlic , Glutathione Peroxidase , Hyperglycemia , Lipid Peroxides , Models, Animal , Oxidative Stress , Superoxide Dismutase , Thiobarbiturates , Thiobarbituric Acid Reactive SubstancesABSTRACT
Milium is an asymptomatic, tiny, subepidermal, keratinous cyst found primarily on the cheek and eyelids. Milium is thought to result from pilosebaceous or eccrine duct plugging. Secondary milium develop when other underlying factors are present such as bullous diseases, various inflammatory skin diseases, and trauma. We report an 8-year-old boy who had a solitary, dome-shaped, whitish papule with 2x3 mm gray macule at the site, pricked by pencil. Histopathologically, the lesion showed the typical findings of milium and foreign body reaction caused by graphite. We treated this using punch excision and there has been no evidence of recurrence for 7 months.
Subject(s)
Child , Humans , Cheek , Eyelids , Foreign-Body Reaction , Graphite , Keratins , Recurrence , Skin DiseasesABSTRACT
Collagenomas, or connective tissue nevi of the collagen type, represent a hamartomatous overgrowth of normal collagen. Isolated collagenoma is rare and most commonly presents in childhood. We herein report a rare case of congenital isolated collagenoma on the scalp without any associated abnormality. A 4-year-old boy with normal development presented with 2x1.5 cm sized, soft, dome-shaped brownish nodule on the scalp. Histopathologic study revealed collagen bundles with thickened appearance, a condition consistent with collagenoma.
Subject(s)
Collagen , Connective Tissue , Nevus , Child, Preschool , ScalpABSTRACT
Seborrheic keratosis is a common benign skin tumor originating from keratinocytes. In most instances, their etiology is unknown; however, there are independent risk factors such as genetic propensity, cumulative exposure to sunlight, human papillomavirus and epidermal growth factors. We report a case of seborrheic keratosis which occurred at the operation site 2 months postoperatively. This case may suggest that growth factors being induced by wound healing make a seborrheic keratosis on the operation site. To the best of our knowledge, this is a rare case of seborrheic keratosis on the operation site.
Subject(s)
Humans , Epidermal Growth Factor , Intercellular Signaling Peptides and Proteins , Keratinocytes , Keratosis, Seborrheic , Risk Factors , Skin , Sunlight , Wound HealingABSTRACT
Pseudoaneurysms of the superficial temporal artery are rare lesions. They present as slowly growing pulsating masses of the face or scalp. The common causes are blunt head trauma, penetrating wounds or interventional procedures. We report here on a rare case of superficial temporal artery pseudoaneurysm in a 44-year-old woman who presented with a pulsating mass, and this mass occurred on the left temporal area 2 weeks after performing a skin punch biopsy.
Subject(s)
Adult , Female , Humans , Aneurysm, False , Biopsy , Head Injuries, Penetrating , Scalp , Skin , Temporal ArteriesABSTRACT
Milium-like syringoma is a rare clinical variant of syringoma, characterized by 1~2 mm, yellowish-white, domed papules. Milium-like syringoma can be clinically mistaken for milia because the lesions are usually similar in appearance. Histopathological examination showed keratin-filled cysts in the papillary dermis and numerous tadpole-shaped epithelial strands in the upper half of the dermis below the cyst. Moreover, most cases report the direct connection between the epithelial strands and the wall of the keratin-filled cyst. We report a rare case of milium-like syringoma in an 8-year-old girl.
Subject(s)
Child , Humans , Dermis , SyringomaABSTRACT
Diffuse plane xanthoma is a group of plane xanthomas that present in yellow to yellowish-brown flat patches on the periorbital area, neck, upper trunk and flexural folds. It is rare and often associated with reticulo-endothelial malignancies such as multiple myeloma, monoclonal gammopathy of unknown significance and other lympho-proliferative disorders. We report a case of diffuse plane xanthoma associated with monoclonal gammopathy of unknown significance and diffuse large B cell lymphoma in a 75 year-old woman.
Subject(s)
Lymphoma, B-Cell , Multiple Myeloma , Neck , Paraproteinemias , XanthomatosisABSTRACT
Milia en plaque (MEP) is an unusual and rare variant of milia characterized by tiny papules overlying an erythematous plaque. The majority of cases have been described as occurring around the ears. The histopathologic finding is consistent with milia. Despite its benign nature and lack of symptoms, MEP raises cosmetic concerns. We report a case of MEP occurring on the left 3rd finger, an unusual location, in a 2-year-old girl.
Subject(s)
Cosmetics , Ear , Fingers , Child, PreschoolABSTRACT
BACKGROUND: Ingrown toenail is a common disorder that occurs most frequently in the big toe and gives affected patient great discomfort and pain. Granulation tissue of nail wall results from ulceration and inflammation by excessive contact between the nail edge and the soft tissues of the nail wall and induces aggravation of the ingrown toenail. OBJECTIVE: To decide whether removal of granulation tissue by electrocautery or not with lateral nail avulsion and matricectomy is the effective treatment in ingrown toenails with granulation tissue. METHODS: Randomized clinical trial with 12 month follow-up evaluations performed by observers. 33 patients with a total of 37 ingrown toenails were treated partial nail avulsion followed by mastricectomy and removal of granulation (granulation removal group), and 36 patients with 40 ingrown toenails were treated without removal of granulation tissue (control group). The determinations of effectiveness were based on the recurrence rate, duration of post-operative pain, wound healing time and post-operative infection. RESULTS: There was no significant difference in recurrence rates between the granulation removal group (15%) and control group (22%). There was a significant difference in the wound healing time between the granulation removal group (13.8 days) and control group (17.6 days). But there were no significant differences for the duration of post-operative pain and post-operative infection between the two groups. There were correlations between recurrence and duration of post-operative pain, wound healing time and post-operative infection. CONCLUSION: Procedures with granulation removal are an effective treatment for the treatment of ingrown nails, with the tendency of shorter times to reach complete recovery. But the effect of granulation removal has limited effect on reducing recurrence.
Subject(s)
Humans , Electrocoagulation , Follow-Up Studies , Granulation Tissue , Inflammation , Nails , Nails, Ingrown , Recurrence , Toes , Ulcer , Wound HealingABSTRACT
Milia-like idiopathic calcinosis cutis is a rare entity. It is characterized by micronodular, whitish papules resembling milia. Histopathological examination shows small nodular foci of calcium within the superficial dermis, which are surrounded by thick collagen and inflammatory cells. Although the pathogenesis and treatment remain unclear, spontaneous resolution of the lesions may occur. We report a case of milia-like idiopathic calcinosis cutis in a 7-year-old girl who improved after treatment with tretinoin cream.
Subject(s)
Child , Humans , Calcinosis , Calcium , Collagen , Dermis , TretinoinABSTRACT
Nevus lipomatosus cutaneous superficialis (NLCS) is a fairly uncommon lesion characterized by ectopic adipose tissue in the dermis. It presents as soft yellowish papules or cerebriform plaques occurring usually on the buttock or thigh with a wrinkled surface. We report a case of NLCS in 38-year-old female who presented reddish brown colored cerebriform tumors on her buttock and was treated by CO2 Laser. To our knowledge this is the first case of NLCS treated by CO2 Laser, path of except by excisional surgery.
Subject(s)
Adult , Female , Humans , Adipose Tissue , Buttocks , Dermis , Lasers, Gas , Nevus , ThighABSTRACT
Estrogen dermatitis is a rare cutaneous disorder characterized by recurrent cyclic eruptions during the luteal phase of the menstrual cycle. The clinical manifestations include pruritus, urticaria, vesicles, papules and eczematous eruptions. A 22-year-old female patient presented with a skin lesion on the back of 6 years periodic duration. She had been recurrently suffering from pruritic eruptions that appear during the luteal phase of the menstrual cycle and resolve after menses. An intradermal skin test to estrogen showed a positive result, but showed negative results to progesterone. After antiestrogen tamoxifen therapy, the lesions were found to have significantly improved.